Received: JAccepted: FebruPublished: April 1, 2021Ĭopyright: © 2021 Yang et al. PLoS Biol 19(4):Īcademic Editor: Jozsef Csicsvari, Institute of Science and Technology Austria, AUSTRIA (2021) Anesthetics fragment hippocampal network activity, alter spine dynamics, and affect memory consolidation. Thus, different anesthetics distinctly alter hippocampal network dynamics, synaptic connectivity, and memory consolidation, with implications for GA strategy appraisal in animal research and clinical settings.Ĭitation: Yang W, Chini M, Pöpplau JA, Formozov A, Dieter A, Piechocinski P, et al. Correspondingly, memory consolidation was impaired after exposure to Keta/Xyl and MMF, but not Iso.
#Memory master anesthesia iso
Iso anesthesia most closely resembled unperturbed activity during wakefulness and sleep, and network alterations recovered more readily than with Keta/Xyl and MMF. CA1 network activity under all 3 anesthetics was different to natural sleep.
GAs robustly reduced spiking activity, decorrelated cellular ensembles, albeit with distinct activity signatures, and altered spine dynamics.
Using extracellular recordings, chronic 2-photon imaging, and behavioral analysis, we monitor the effects of isoflurane (Iso), medetomidine/midazolam/fentanyl (MMF), and ketamine/xylazine (Keta/Xyl) on network activity and structural spine dynamics in the hippocampal CA1 area of adult mice. How different types of general anesthetics (GAs) affect the hippocampus, a brain region central to memory formation and consolidation, is poorly understood. Yet, long-term memory impairment is an undesirable side effect. General anesthesia is characterized by reversible loss of consciousness accompanied by transient amnesia.
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